Bison can stand on its own or substitute beef in any of your favorite recipes. Either way, because the meat is so lean, it does require a little extra attention and a little less cooking.
Bottom line: be careful not to overcook your bison.

Following are some suggestions:

Ground Bison. For bison burgers consider cooking 2-3 minutes less than beef. It will have the best flavor and texture if it is cooked rare or medium-rare. If you are browning the bison for tacos or your favorite recipe, there is no need to drain as there will rarely be any grease.

Roasts, Brisket and Short Ribs. Low temperature, high moisture and a good amount of time will yield the best results.

Steaks. Tender cuts such as steaks have little fat marbling which means it is very susceptible to drying out. Medium-rare will give you a mouth-watering, flavorful bison steak.